Phf10^tm1.1Grc
Targeted Allele Detail

Summary

• Symbol: Phf10^tm1.1Grc
• Name: PHD finger protein 10; targeted mutation 1.1, Gerald R Crabtree
• MGI ID: MGI:5439538
• Synonyms: BAF 45a floxed
• Gene: Phf10 Location: Chr17:15165271-15181535 bp, - strand Genetic Position: Chr17, 8.95 cM, cytoband A2
• Alliance: Phf10^tm1.1Grc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting scheme was designed to flank exons 3 and 4 of the gene with loxP sites. A loxP-flanked TK-neomycin cassette was first introduced to intron 4, then excised to leave a single loxP site. The same loxP-flanked TK-neomycin cassette was then placed in intron 2 to create a floxed drug selection marker. Cre-mediated recombination removed the neo cassette and left exons 3 and 4 floxed. (J:101977)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Phf10^tm1.1Grc/Phf10^tm1.1Grc	involves: 129S6/SvEvTac * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
normal phenotype	√
no abnormal phenotype detected	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Phf10 Mutation: 27 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 3 reference(s)