Fbn1^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Fbn1^tm1.1Itl
• Name: fibrillin 1; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5439622
• Synonyms: Fbn1^Lox
• Gene: Fbn1 Location: Chr2:125142514-125348417 bp, - strand Genetic Position: Chr2, 61.38 cM, cytoband F
• Alliance: Fbn1^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187484
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette and left exon 1 floxed. (J:187484)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbn1 Mutation: 173 strains or lines available

References

• Original: J:187484 Cook JR, et al., Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis. 2012 Aug;50(8):635-41
• All: 6 reference(s)