Bap1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Bap1^tm1.1Geno
• Name: Brca1 associated protein 1; targeted mutation 1.1, Genoway
• MGI ID: MGI:5439652
• Synonyms: Bap1^fl
• Gene: Bap1 Location: Chr14:30973407-30981901 bp, + strand Genetic Position: Chr14, 19.09 cM
• Alliance: Bap1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187380
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:187380)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bap1 Mutation: 38 strains or lines available

References

• Original: J:187380 Dey A, et al., Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012 Sep 21;337(6101):1541-6
• All: 6 reference(s)