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Bap1tm1.2Geno
Targeted Allele Detail
Summary
Symbol: Bap1tm1.2Geno
Name: Brca1 associated protein 1; targeted mutation 1.2, Genoway
MGI ID: MGI:5439653
Synonyms: Bap1-
Gene: Bap1  Location: Chr14:30973407-30981901 bp, + strand  Genetic Position: Chr14, 19.09 cM
Alliance: Bap1tm1.2Geno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:187380
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and FRT flanked neo cassette were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 5 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 4 and 5. (J:187380)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
involves: C57BL/6
 
Phenotypes:
Affected Systems
show or hide all annotated terms
 
embryo
embryonic growth retardation
growth/size/body
embryonic growth retardation
mortality/aging
embryonic lethality during organogenesis, complete penetrance
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bap1 Mutation:  38 strains or lines available
References
Original:  J:187380 Dey A, et al., Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012 Sep 21;337(6101):1541-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory

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