Mcm9^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Mcm9^tm1.1Geno
• Name: minichromosome maintenance 9 homologous recombination repair factor; targeted mutation 1.1, Genoway
• MGI ID: MGI:5439838
• Gene: Mcm9 Location: Chr10:53412411-53506535 bp, - strand Genetic Position: Chr10, 27.21 cM, cytoband B3
• Alliance: Mcm9^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187623
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream, of exon 2. Cre-mediated recombination removed exon 1, exon 2 and the neo cassette. Western blot analysis confirmed the absence of protein expression in testis. (J:187623)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcm9 Mutation: 75 strains or lines available

References

• Original: J:187623 Lutzmann M, et al., MCM8- and MCM9-Deficient Mice Reveal Gametogenesis Defects and Genome Instability Due to Impaired Homologous Recombination. Mol Cell. 2012 Aug 24;47(4):523-34
• All: 3 reference(s)