Nlrc3^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Nlrc3^tm1Bhk
• Name: NLR family, CARD domain containing 3; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:5439971
• Gene: Nlrc3 Location: Chr16:3762871-3794496 bp, - strand Genetic Position: Chr16, 2.32 cM
• Alliance: Nlrc3^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187586
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 3, which encodes the nucleotide-binding domain. RT-PCR confirmed the absence of transcript expression. (J:187586)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc3 Mutation: 54 strains or lines available

References

• Original: J:187586 Schneider M, et al., The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-kappaB. Nat Immunol. 2012 Aug 5;13(9):823-31
• All: 5 reference(s)