Crhr1^tm2Jde
Targeted Allele Detail

Summary

• Symbol: Crhr1^tm2Jde
• Name: corticotropin releasing hormone receptor 1; targeted mutation 2, Jan Deussing
• MGI ID: MGI:5440011
• Synonyms: Crhr1^tZ
• Gene: Crhr1 Location: Chr11:104023681-104066349 bp, + strand Genetic Position: Chr11, 67.77 cM
• Alliance: Crhr1^tm2Jde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187372
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. A construct, which contained (5' to 3') an att site, loxP site, FRT site, splace acceptor, T2A cleavage site, tau/lacZ/flag reporter cassette, FRT site, neo cassette, attP site, PGK promoter and FRT site, was inserted into intron 2. (J:187372)

Generation of a series of Crhr1 alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crhr1 Mutation: 28 strains or lines available

References

• Original: J:187372 Kuhne C, et al., Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele. J Comp Neurol. 2012 Oct 1;520(14):3150-80
• All: 2 reference(s)