Kansl1/Mapt^tm1.1Cole
Targeted Allele Detail

Summary

• Symbol: Kansl1/Mapt^tm1.1Cole
• Name: microtubule-associated protein tau; targeted mutation 1.1, Michael Coleman
• MGI ID: MGI:5440076
• Synonyms: tau^P301L
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Kansl1/Mapt^tm1.1Cole page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188213
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Duplication, Insertion, Single point mutation
• Kansl1/Mapt^tm1.1Cole involves 1 genes/genome features (Mapt) View all
• Mutation details: Exon 10 was replaced with a floxed neo cassette and a modified exon 10 in which a C to T transition results in the amino acid substitution of leucine for proline at position 301 (P301L). Cre-mediated recombination removed the neo cassette. A 35 kb tandem duplication spans exons in the 3' ends of Mapt and Kansl1. Transcript expression is not effected by this duplication. (J:188213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 430 strains or lines available

References

• Original: J:188213 Gilley J, et al., Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse. Neurobiol Aging. 2012 Mar;33(3):621.e1-621.e15
• All: 3 reference(s)