Mapt^tm2.1Cole
Targeted Allele Detail

Summary

• Symbol: Mapt^tm2.1Cole
• Name: microtubule-associated protein tau; targeted mutation 2.1, Michael Coleman
• MGI ID: MGI:5440076
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm2.1Cole page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188213
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted
• Mutations: Duplication, Insertion
• Mapt^tm2.1Cole involves 1 genes/genome features (Kansl1) View all
• Mutation details: A 35 kb tandem duplication that spans exons in the 3' ends of Mapt (exons 10-13) and Kansl1 (exons 8-14) occurred during the engineering of the Mapt^tm1.1Cole allele. Transcript expression of the original, complete genes is not effected by this duplication. (J:188213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 447 strains or lines available

References

• Original: J:188213 Gilley J, et al., Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse. Neurobiol Aging. 2012 Mar;33(3):621.e1-621.e15
• All: 3 reference(s)