Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Rolf Kemler
• MGI ID: MGI:5440174
• Synonyms: ROSA26^Beta
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187739
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Ctnnb1)Kem} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ctnnb1 (MGI:88276)

• Mutation details: A splice acceptor site, floxed beta-geo stop cassette and a full length Ctnnb1 gene were inserted via homologous recombination. Cre mediated recombination removed the floxed beta-geo stop cassette. (J:187739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:187739 Rudloff S, et al., Differential requirements for beta-catenin during mouse development. Development. 2012 Oct;139(20):3711-21
• All: 2 reference(s)