Erc2^tm1Toh
Targeted Allele Detail

Summary

• Symbol: Erc2^tm1Toh
• Name: ELKS/RAB6-interacting/CAST family member 2; targeted mutation 1, Toshihisa Ohtsuka
• MGI ID: MGI:5440304
• Synonyms: Erc2^tm1Tmos
• Gene: Erc2 Location: Chr14:27344385-28200494 bp, + strand Genetic Position: Chr14, 16.51 cM
• Alliance: Erc2^tm1Toh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187689
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 sequence, coding for the first 130 amino acids of the protein, was replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in retinal extracts from homozygous mice. (J:187689)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erc2 Mutation: 112 strains or lines available

References

• Original: J:187689 Tom Dieck S, et al., Deletion of the Presynaptic Scaffold CAST Reduces Active Zone Size in Rod Photoreceptors and Impairs Visual Processing. J Neurosci. 2012 Aug 29;32(35):12192-12203
• All: 10 reference(s)