Tg(Prnp-HSPB1*R136W)1Kolb
Transgene Detail

Summary

• Symbol: Tg(Prnp-HSPB1*R136W)1Kolb
• Name: transgene insertion 1, Stephen Kolb
• MGI ID: MGI:5440458
• Synonyms: PrP-HSPB1 (R136W)
• Transgene: Tg(Prnp-HSPB1*R136W)1Kolb Location: unknown
• Alliance: Tg(Prnp-HSPB1*R136W)1Kolb page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-HSPB1*R136W)1Kolb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HSPB1 (3315)

  Hspb1

  (MGI:96240)

• Mutation details: Mouse prion protein promoter drives expression of the human HSBP1 open reading frame bearing a C406T nucleotide (R136W amino acid) substitution. Line 1 was generated. (J:188399)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:188399 Srivastava AK, et al., Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice. Neurobiol Dis. 2012 Aug;47(2):163-73
• All: 1 reference(s)