Fhod3^tm1Hsum
Targeted Allele Detail

Summary

• Symbol: Fhod3^tm1Hsum
• Name: formin homology 2 domain containing 3; targeted mutation 1, Hideki Sumimoto
• MGI ID: MGI:5440613
• Synonyms: Fhod3^lacZ
• Gene: Fhod3 Location: Chr18:24841680-25266558 bp, + strand Genetic Position: Chr18, 13.18 cM
• Alliance: Fhod3^tm1Hsum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187358
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a lacZ/neo cassette. Western blot analysis confirmed the absence of protein expression in E9.5 embryos. (J:187358)

Expression

In Mice Carrying this Mutation:	100 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fhod3 Mutation: 92 strains or lines available

References

• Original: J:187358 Kan-o M, et al., Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis. Biol Open. 2012;1(9):889-896
• All: 6 reference(s)