Plin5^tm1Tosu
Targeted Allele Detail

Summary

• Symbol: Plin5^tm1Tosu
• Name: perilipin 5; targeted mutation 1, Takashi Osumi
• MGI ID: MGI:5440666
• Gene: Plin5 Location: Chr17:56418601-56424596 bp, - strand Genetic Position: Chr17, 29.16 cM
• Alliance: Plin5^tm1Tosu page

Absence of lipid droplets in Plin5^tm1Tosu/Plin5^tm1Tosu hearts

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188390
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette replaced exons 2 through 4. Western blot analysis confirmed the absence of protein expression in the heart. (J:188390)

Generation of the Plin5^tm1Tosu allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plin5 Mutation: 22 strains or lines available

References

• Original: J:188390 Kuramoto K, et al., Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation. J Biol Chem. 2012 Jul 6;287(28):23852-63
• All: 4 reference(s)