Setdb1^tm1.1Yshk
Targeted Allele Detail

Summary

• Symbol: Setdb1^tm1.1Yshk
• Name: SET domain, bifurcated 1; targeted mutation 1.1, Yoichi Shinkai
• MGI ID: MGI:5440719
• Synonyms: Eset CKO, ESET^{(exons15&16)Flox}
• Gene: Setdb1 Location: Chr3:95230836-95264513 bp, - strand Genetic Position: Chr3, 40.74 cM, cytoband F2
• Alliance: Setdb1^tm1.1Yshk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 15 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 16 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:188475)

Expression

In Mice Carrying this Mutation:	11 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Setdb1 Mutation: 56 strains or lines available

References

• Original: J:188475 Matsui T, et al., Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET. Nature. 2010 Apr 8;464(7290):927-31
• All: 18 reference(s)