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Map3k12tm1.1Adia
Targeted Allele Detail
Summary
Symbol: Map3k12tm1.1Adia
Name: mitogen-activated protein kinase kinase kinase 12; targeted mutation 1.1, Aaron DiAntonio
MGI ID: MGI:5440722
Synonyms: DLKlox
Gene: Map3k12  Location: Chr15:102406079-102425311 bp, - strand  Genetic Position: Chr15, 57.63 cM, cytoband F3
Alliance: Map3k12tm1.1Adia page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188476
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP cassette was inserted upstream of exon 8. An additional loxP site was inserted downstream of exon 11. Flp-mediated recombination removed the neo cassette and left exons 8 through 11 floxed. These exons code the kinase domain. (J:188476)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k12 Mutation:  39 strains or lines available
References
Original:  J:188476 Miller BR, et al., A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci. 2009 Apr;12(4):387-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory