Map3k12^tm1.2Adia
Targeted Allele Detail

Summary

• Symbol: Map3k12^tm1.2Adia
• Name: mitogen-activated protein kinase kinase kinase 12; targeted mutation 1.2, Aaron DiAntonio
• MGI ID: MGI:5440724
• Gene: Map3k12 Location: Chr15:102406079-102425311 bp, - strand Genetic Position: Chr15, 57.63 cM, cytoband F3
• Alliance: Map3k12^tm1.2Adia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188476
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination ore Map3k12^tm1.1Adia removes exons 8 through 11. Western blot analysis confirmed the absence of protein expression in the brain. (J:188476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k12 Mutation: 39 strains or lines available

References

• Original: J:188476 Miller BR, et al., A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci. 2009 Apr;12(4):387-9
• All: 5 reference(s)