Mfn1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Mfn1^tm1.1Arte
• Name: mitofusin 1; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5440838
• Synonyms: Mfn1^loxP
• Gene: Mfn1 Location: Chr3:32583614-32633388 bp, + strand Genetic Position: Chr3, 15.75 cM, cytoband B
• Alliance: Mfn1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188337
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:188337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mfn1 Mutation: 45 strains or lines available

References

• Original: J:188337 Lee S, et al., Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Hum Mol Genet. 2012 Nov 15;21(22):4827-35
• All: 4 reference(s)