Mfn2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Mfn2^tm1.1Arte
• Name: mitofusin 2; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5440839
• Synonyms: Mfn2^loxP
• Gene: Mfn2 Location: Chr4:147958056-147989161 bp, - strand Genetic Position: Chr4, 78.56 cM
• Alliance: Mfn2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188337
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 5 and a loxP site was inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:188337)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mfn2 Mutation: 27 strains or lines available

References

• Original: J:188337 Lee S, et al., Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons. Hum Mol Genet. 2012 Nov 15;21(22):4827-35
• All: 7 reference(s)