Wnk1^tm2Cihu
Targeted Allele Detail

Summary

• Symbol: Wnk1^tm2Cihu
• Name: WNK lysine deficient protein kinase 1; targeted mutation 2, Chou-Long Huang
• MGI ID: MGI:5440881
• Synonyms: KS-WNK1-KO
• Gene: Wnk1 Location: Chr6:119900930-120015633 bp, - strand Genetic Position: Chr6, 56.86 cM
• Alliance: Wnk1^tm2Cihu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168700
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 4a. Northern blot analysis confirmed the absence of transcript expression of the kidney-specific (KS) isoform. (J:168700)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnk1 Mutation: 115 strains or lines available

References

• Original: J:168700 Liu Z, et al., Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet. 2011 Mar 1;20(5):855-66
• All: 4 reference(s)