Arfgef2^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Arfgef2^tm1Itl
• Name: ARF guanine nucleotide exchange factor 2; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:5440903
• Gene: Arfgef2 Location: Chr2:166647508-166739972 bp, + strand Genetic Position: Chr2, 87.22 cM
• Alliance: Arfgef2^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187673
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 5 were replaced with an FRT- and loxP flanked neo cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:187673)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arfgef2 Mutation: 90 strains or lines available

References

• Original: J:187673 Zhang J, et al., Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration. J Neurosci. 2012 Sep 5;32(36):12619-29
• All: 1 reference(s)