Il27^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Il27^tm1Lex
• Name: interleukin 27; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5440910
• Gene: Il27 Location: Chr7:126188182-126194113 bp, - strand Genetic Position: Chr7, 69.18 cM
• Alliance: Il27^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:187660
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A lacZ/neo cassette replaced exons 2 and 3. (J:187660)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il27 Mutation: 22 strains or lines available

References

• Original: J:187660 Hall AO, et al., The Cytokines Interleukin 27 and Interferon-gamma Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology. Immunity. 2012 Sep 21;37(3):511-23
• All: 3 reference(s)