Elavl3^tm1.1Rbd
Targeted Allele Detail

Summary

• Symbol: Elavl3^tm1.1Rbd
• Name: ELAV like RNA binding protein 3; targeted mutation 1.1, Robert B Darnell
• MGI ID: MGI:5440933
• Gene: Elavl3 Location: Chr9:21926301-21963319 bp, - strand Genetic Position: Chr9, 8.07 cM
• Alliance: Elavl3^tm1.1Rbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188326
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A self-excising neo cassette replaced three exons, including those with the first three translation initiation sites. Western blot analysis confirmed the absence of protein expression in the forebrain, hindbrain and spinal cord. Cre-mediated recombination removed the neo cassette. (J:188326)

Expression

In Mice Carrying this Mutation:

8 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elavl3 Mutation: 28 strains or lines available

References

• Original: J:188326 Ince-Dunn G, et al., Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability. Neuron. 2012 Sep 20;75(6):1067-80
• All: 3 reference(s)