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Gsk3btm2138.1Arte
Targeted Allele Detail
Summary
Symbol: Gsk3btm2138.1Arte
Name: glycogen synthase kinase 3 beta; targeted mutation 2138.1, TaconicArtemis
MGI ID: MGI:5440976
Synonyms: GSK3betaASKA, GSK3betatm2138(V110I,L132A,F175L)Arte, Gsk3btm1Arte
Gene: Gsk3b  Location: Chr16:37909363-38066446 bp, + strand  Genetic Position: Chr16, 26.54 cM, cytoband B4
Alliance: Gsk3btm2138.1Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:188272
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsNucleotide substitutions result in the amino acid sibstitution of isoleucine to valine at position 110 (V110I), alanine for leucine at position 132 (L132A) and leucine for phenylalanine at position 175 (F175L). Flp-mediated recombination removed the FRT-flanked neo cassette. (J:188272)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gsk3b Mutation:  113 strains or lines available
References
Original:  J:188272 Chen M, et al., Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci. 2012 Sep 26;32(39):13439-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory