Mis18a^tm1.1Kiik
Targeted Allele Detail

Summary

• Symbol: Mis18a^tm1.1Kiik
• Name: MIS18 kinetochore protein A; targeted mutation 1.1, Keun Il Kim
• MGI ID: MGI:5441068
• Synonyms: Misalpha^f, Misalpha^floxed
• Gene: Mis18a Location: Chr16:90516200-90524259 bp, - strand Genetic Position: Chr16, 51.87 cM, cytoband C3.3
• Alliance: Mis18a^tm1.1Kiik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188023
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted usptream of exon 1. A loxp and FRT-flanked neo cassette was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exons 1 and 2 floxed. (J:188023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mis18a Mutation: 13 strains or lines available

References

• Original: J:188023 Kim IS, et al., Roles of Mis18alpha in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell. 2012 May 11;46(3):260-73
• All: 3 reference(s)