Usp22^tm1Dfan
Targeted Allele Detail

Summary

• Symbol: Usp22^tm1Dfan
• Name: ubiquitin specific peptidase 22; targeted mutation 1, Deyu Fang
• MGI ID: MGI:5441074
• Gene: Usp22 Location: Chr11:61042611-61065881 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Usp22^tm1Dfan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188021
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:188021)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp22 Mutation: 33 strains or lines available

References

• Original: J:188021 Lin Z, et al., USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012 May 25;46(4):484-94
• All: 1 reference(s)