Tg(Rho*G90D*A337V)202Sie
Transgene Detail

Summary

• Symbol: Tg(Rho*G90D*A337V)202Sie
• Name: transgene insertion 202, Paul A Sieving
• MGI ID: MGI:5441362
• Synonyms: G⁺
• Transgene: Tg(Rho*G90D*A337V)202Sie Location: unknown
• Alliance: Tg(Rho*G90D*A337V)202Sie page

Transgene origin

• Strain of Origin: C57BL/6 x DBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rho*G90D*A337V)202Sie expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rho (MGI:97914)

• Mutation details: The mouse sequence was mutated to replace glycine with an aspartic acid at position (G90D) and alanine with valine at position 337 (A337V). The second mutation allows for identification with the human-specific antibody. Several lines were establisehd from founders 116 and 202. Line 116 contains two to three more copies of the transgene compared with line 202. (J:188632)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:188632 Sieving PA, et al., Constitutive "light" adaptation in rods from G90D rhodopsin: a mechanism for human congenital nightblindness without rod cell loss. J Neurosci. 2001 Aug 1;21(15):5449-60
• All: 2 reference(s)