Xbp1^tm3Glm
Targeted Allele Detail

Summary

• Symbol: Xbp1^tm3Glm
• Name: X-box binding protein 1; targeted mutation 3, Laurie H Glimcher
• MGI ID: MGI:5441521
• Synonyms: XBP-1^floxneo
• Gene: Xbp1 Location: Chr11:5470659-5475893 bp, + strand Genetic Position: Chr11, 3.61 cM
• Alliance: Xbp1^tm3Glm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131028
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 1 and an additional loxP site was inserted into intron 2. (J:131028)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xbp1 Mutation: 29 strains or lines available

References

• Original: J:131028 Hetz C, et al., Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):757-62
• All: 2 reference(s)