Zfp36^tm4.1Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36^tm4.1Pjb
• Name: zinc finger protein 36; targeted mutation 4.1, Perry J Blackshear
• MGI ID: MGI:5441582
• Synonyms: Zfp36^flox, Zfp36^tm1.1Xen
• Gene: Zfp36 Location: Chr7:28076208-28078680 bp, - strand Genetic Position: Chr7, 16.72 cM
• Alliance: Zfp36^tm4.1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188677
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of the exon 2. An additional loxP site was inserted downstream of the exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:188677)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfp36 Mutation: 19 strains or lines available

References

• Original: J:188677 Qiu LQ, et al., Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype. J Immunol. 2012 May 15;188(10):5150-9
• All: 16 reference(s)