Rptor^tm1Ahir
Targeted Allele Detail

Summary

• Symbol: Rptor^tm1Ahir
• Name: regulatory associated protein of MTOR, complex 1; targeted mutation 1, Atsushi Hirao
• MGI ID: MGI:5441589
• Synonyms: Raptor^fl, Rptor^tm1Sama
• Gene: Rptor Location: Chr11:119493731-119790402 bp, + strand Genetic Position: Chr11, 83.96 cM, cytoband E2
• Alliance: Rptor^tm1Ahir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188676
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a second loxP site followed by an FRT flanked neo cassette were inserted in intron 2. Subsequent flp recombinase expression removed the neo selection cassette. (J:190434)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rptor Mutation: 117 strains or lines available

References

• Original: J:188676 Ohtani M, et al., Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. J Immunol. 2012 May 15;188(10):4736-40
• All: 8 reference(s)