Acvr2b^tm1.1Zuk
Targeted Allele Detail

Summary

• Symbol: Acvr2b^tm1.1Zuk
• Name: activin receptor IIB; targeted mutation 1.1, Martin M Matzuk
• MGI ID: MGI:5441718
• Synonyms: Acvr2b^flox
• Gene: Acvr2b Location: Chr9:119231184-119264061 bp, + strand Genetic Position: Chr9, 71.33 cM
• Alliance: Acvr2b^tm1.1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188599
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:188599)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr2b Mutation: 27 strains or lines available

References

• Original: J:188599 Lee SJ, et al., Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):E2353-60
• All: 6 reference(s)