Ano1^tm1Jrr
Targeted Allele Detail

Summary

• Symbol: Ano1^tm1Jrr
• Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1, Jason Rock
• MGI ID: MGI:5442019
• Synonyms: Tmem16a::GFP
• Gene: Ano1 Location: Chr7:144142286-144305711 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Ano1^tm1Jrr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188769
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous stop codon was replaced with an amino acid polylinker RDPRVPVAT and EGFP to generate a fusion protein. A neo cassette was inserted downstream of the EGFP. (J:188769)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano1 Mutation: 60 strains or lines available

References

• Original: J:188769 Huang F, et al., Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354-9
• All: 6 reference(s)