b2b1594Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1594Clo
• Name: Mutant line 1594; Bench to Bassinet Program (B2B/CVDC), mutation 1594 Cecilia Lo
• MGI ID: MGI:5442115
• Synonyms: Zombie
• Gene: b2b1594Clo Location: unknown
• Alliance: b2b1594Clo page

Mutant 1594-004-NA shows cleft palate

Show the 11 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, b2b1594Clo, and may be present in stocks carrying this mutation.

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b1594Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiac phenotype: Biventricular hypertrophy, aortic arch anomalies such as vascular ring
Non-cardiac phenotype: Cleft palate, microganthia, necrotic gut, short digits with oligodactyly/syndactyly, and club foot

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
2705	Aortic arch abnormal branching
2760	Vascular ring
4163	Micrognathia
4171	Clubfoot (talipes)
4174	Syndactyly
4876	Cleft palate
7505	Biventricular hypertrophy

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)