Sec63^tm1Som
Targeted Allele Detail

Summary

• Symbol: Sec63^tm1Som
• Name: SEC63 homolog, protein translocation regulator; targeted mutation 1, Stefan Somlo
• MGI ID: MGI:5442171
• Synonyms: Sec63^flox
• Gene: Sec63 Location: Chr10:42637492-42708510 bp, + strand Genetic Position: Chr10, 22.89 cM
• Alliance: Sec63^tm1Som page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188763
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 2 was floxed and an FRT-flanked neo cassette was inserted into IVS2. (J:188763)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sec63 Mutation: 40 strains or lines available

References

• Original: J:188763 Fedeles SV, et al., A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat Genet. 2011 Jul;43(7):639-47
• All: 5 reference(s)