Hnrnpl^tm1.1Tmo
Targeted Allele Detail

Summary

• Symbol: Hnrnpl^tm1.1Tmo
• Name: heterogeneous nuclear ribonucleoprotein L; targeted mutation 1.1, Tarik Moroy
• MGI ID: MGI:5442362
• Synonyms: hn RNP L^fl
• Gene: Hnrnpl Location: Chr7:28507971-28521693 bp, + strand Genetic Position: Chr7, 16.93 cM, cytoband A3
• Alliance: Hnrnpl^tm1.1Tmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188749
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette and left exons 2 through 6 floxed. (J:188749)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnrnpl Mutation: 33 strains or lines available

References

• Original: J:188749 Gaudreau MC, et al., Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells. J Immunol. 2012 Jun 1;188(11):5377-88
• All: 3 reference(s)