Tyr^c-Wtsi
Spontaneous Allele Detail

Summary

• Symbol: Tyr^c-Wtsi
• Name: tyrosinase; albino Wellcome Trust Sanger Institute
• MGI ID: MGI:5442732
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-Wtsi page

Mutation origin

• Mutant Cell Line: EPD0176_3_A10
• Germline Transmission: Earliest citation of germline transmission: J:188986
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The mutation is a 14.3 kb deletion of the tyrosinase gene spanning from 940 bp 5' of exon 1 (including the minimal promoter region) to 3.75 kb 3' of exon 2. This mutation arose spontaneously in EUCOMM embryonic stem (ES) cell clone EPD0176_3_A10, which was produced from JM8.N4 embryonic stem (ES) cells. (J:188986)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 379 strains or lines available

References

• Original: J:188986 Ryder E, et al., An albino C57BL/6N mouse strain. MGI Direct Data Submission. 2012
• All: 2 reference(s)