Cdcp1^tm1.2Moas
Targeted Allele Detail

Summary

• Symbol: Cdcp1^tm1.2Moas
• Name: CUB domain containing protein 1; targeted mutation 1.2, Mark Moasser
• MGI ID: MGI:5442763
• Gene: Cdcp1 Location: Chr9:122999889-123045103 bp, - strand Genetic Position: Chr9, 73.92 cM
• Alliance: Cdcp1^tm1.2Moas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194368
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a FRT site-flanked NEO cassette was utilized in the construction of this mutant. A loxP site and the selection cassette were inserted downstream of exon 1 of the targeted gene, and another loxP site was inserted upstream of exon 1. Flp-mediated recombination removed the neo cassette and cre-mediated recombination removed exon 1. No gene product (protein) is detected by Western blot analysis of skin and intestine from homozygous mice. (J:194368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdcp1 Mutation: 49 strains or lines available

References

• Original: J:194368 Spassov DS, et al., Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor cross-talk in unanchored cells. Cancer Res. 2013 Feb 1;73(3):1168-79
• All: 5 reference(s)