Slamf8^tm1Mill
Targeted Allele Detail

Summary

• Symbol: Slamf8^tm1Mill
• Name: SLAM family member 8; targeted mutation 1, Millennium Pharmaceuticals Inc
• MGI ID: MGI:5442794
• Synonyms: Slamf8^deltaE2-4
• Gene: Slamf8 Location: Chr1:172409325-172418135 bp, - strand Genetic Position: Chr1, 79.99 cM, cytoband H2
• Alliance: Slamf8^tm1Mill page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188963
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 2 through 4. RT-PCR confirmed the absence of transcript expression in the spleen. (J:188963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slamf8 Mutation: 14 strains or lines available

References

• Original: J:188963 Wang G, et al., Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages. J Immunol. 2012 Jun 15;188(12):5829-32
• All: 3 reference(s)