Mgat5b^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Mgat5b^tm1.1Itl
• Name: mannoside acetylglucosaminyltransferase 5, isoenzyme B; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5442815
• Synonyms: GnT-Vb^dfl
• Gene: Mgat5b Location: Chr11:116809689-116877774 bp, + strand Genetic Position: Chr11, 81.49 cM
• Alliance: Mgat5b^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 6. An FRT- and loxP flanked neo cassette was inserted downstream of exon 6. Cre-mediated recombination removed exon 6 and the neo cassette. (J:188930)

Generation of the Mgat5b^tm1Itl and Mgat5b^tm1.1Itl alleles

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgat5b Mutation: 66 strains or lines available

References

• Original: J:188930 Lee JK, et al., Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V. J Biol Chem. 2012 Aug 17;287(34):28526-36
• All: 1 reference(s)