Tcap^tm1Rnk
Targeted Allele Detail

Summary

• Symbol: Tcap^tm1Rnk
• Name: titin-cap; targeted mutation 1, Ralph Knoll
• MGI ID: MGI:5443850
• Gene: Tcap Location: Chr11:98274637-98275779 bp, + strand Genetic Position: Chr11, 61.75 cM
• Alliance: Tcap^tm1Rnk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188832
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo/lacZ cassette replaced exons 1 and 2. Western blot analysis confirmed the absence of protein expression. (J:188832)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcap Mutation: 9 strains or lines available

References

• Original: J:188832 Knoll R, et al., Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011 Sep 16;109(7):758-69
• All: 2 reference(s)