Grn^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Grn^tm1.1Geno
• Name: granulin; targeted mutation 1.1, Genoway
• MGI ID: MGI:5443906
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188420
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 4 via homologous recombination. Cre mediated recombination deleted exons 2 - 4. qRT-PCR and immunoblot analysis confirmed the absence of full length RNA and protein expression in the brains from homozygous mice. (J:188420)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 48 strains or lines available

References

• Original: J:188420 Wils H, et al., Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice. J Pathol. 2012 Sep;228(1):67-76
• All: 1 reference(s)