Foxc1^tm1.1Tsku
Targeted Allele Detail

Summary

• Symbol: Foxc1^tm1.1Tsku
• Name: forkhead box C1; targeted mutation 1.1, Tsutomu Kume
• MGI ID: MGI:5443919
• Synonyms: Foxc1^delta
• Gene: Foxc1 Location: Chr13:31990629-31994618 bp, + strand Genetic Position: Chr13, 13.52 cM
• Alliance: Foxc1^tm1.1Tsku page

Hydrocephalus and eye abnormalities in Foxc1^tm1.1Tsku/Foxc1^tm1.1Tsku fetuses

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188816
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed the coding sequence from Foxc1^tm1Tsku. RT-PCR confirmed the absence of transcript expression in embryos. (J:188816)

Generation of the Foxc1^tm1Tsku and Foxc1^tm1.1Tsku alleles

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxc1 Mutation: 29 strains or lines available

References

• Original: J:188816 Sasman A, et al., Generation of conditional alleles for Foxc1 and Foxc2 in mice. Genesis. 2012 Oct;50(10):766-74
• All: 2 reference(s)