Foxc2^tm1.2Tsku
Targeted Allele Detail

Summary

• Symbol: Foxc2^tm1.2Tsku
• Name: forkhead box C2; targeted mutation 1.2, Tsutomu Kume
• MGI ID: MGI:5443921
• Synonyms: Foxc2^delta
• Gene: Foxc2 Location: Chr8:121842910-121845634 bp, + strand Genetic Position: Chr8, 70.33 cM
• Alliance: Foxc2^tm1.2Tsku page

Ventricular septal defect and thin myocardium in Foxc2^tm1.2Tsku/Foxc2^tm1.2Tsku embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188816
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination of Foxc2^tm1.1Tsku removed the coding sequence. RT-PCR confirmed the absence of transcript expression in embryos. (J:188816)

Generation of the Foxc2^tm1.1Tsku and Foxc2^tm1.2Tsku alleles

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxc2 Mutation: 15 strains or lines available

References

• Original: J:188816 Sasman A, et al., Generation of conditional alleles for Foxc1 and Foxc2 in mice. Genesis. 2012 Oct;50(10):766-74
• All: 2 reference(s)