Rspo3^tm1.1Jcob
Targeted Allele Detail

Summary

• Symbol: Rspo3^tm1.1Jcob
• Name: R-spondin 3; targeted mutation 1.1, John Cobb
• MGI ID: MGI:5443941
• Synonyms: Rspo3^F
• Gene: Rspo3 Location: Chr10:29329102-29411863 bp, - strand Genetic Position: Chr10, 16.64 cM, cytoband A4
• Alliance: Rspo3^tm1.1Jcob page

Rspo2^ftls/Rspo2^ftls Rspo3^tm1.1Jcob/Rspo3^tm1.2Jcob Tg(Prrx1-cre)1Cjt/0 double mutants have more severe limb defects than single mutants

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188812
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:188812)

Generation of the Rspo3^tm1.1Jcob and Rspo3^tm1.2Jcob alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rspo3 Mutation: 13 strains or lines available

References

• Original: J:188812 Neufeld S, et al., A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development. Genesis. 2012 Oct;50(10):741-9
• All: 10 reference(s)