Stxbp2^tm1Bdic
Targeted Allele Detail

Summary

• Symbol: Stxbp2^tm1Bdic
• Name: syntaxin binding protein 2; targeted mutation 1, Burton F Dickey
• MGI ID: MGI:5443995
• Gene: Stxbp2 Location: Chr8:3680955-3693644 bp, + strand Genetic Position: Chr8, 1.92 cM, cytoband A1
• Alliance: Stxbp2^tm1Bdic page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Western blot analysis confirmed the absence of protein expression. (J:188931)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stxbp2 Mutation: 36 strains or lines available

References

• Original: J:188931 Kim K, et al., Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15;446(3):383-94
• All: 1 reference(s)