Cldn10^tm1.1Dmu
Targeted Allele Detail

Summary

• Symbol: Cldn10^tm1.1Dmu
• Name: claudin 10; targeted mutation 1.1, Dominik Muller
• MGI ID: MGI:5444004
• Gene: Cldn10 Location: Chr14:119025283-119111937 bp, + strand Genetic Position: Chr14, 62.55 cM
• Alliance: Cldn10^tm1.1Dmu page

Nephrocalcinosis in Cldn10^tm1.1Dmu/Cldn10^tm1.1Dmu Tg(Cdh16-cre)91Igr/0 kidneys

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188580
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:188580)

Generation of the Cldn10^tm1.1Dmu allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn10 Mutation: 22 strains or lines available

References

• Original: J:188580 Breiderhoff T, et al., Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14241-6
• All: 2 reference(s)