Nostrin^tm1Oess
Targeted Allele Detail

Summary

• Symbol: Nostrin^tm1Oess
• Name: nitric oxide synthase trafficker; targeted mutation 1, Stefanie Oess
• MGI ID: MGI:5444008
• Synonyms: Nostrin^flox
• Gene: Nostrin Location: Chr2:68966144-69019674 bp, + strand Genetic Position: Chr2, 39.58 cM
• Alliance: Nostrin^tm1Oess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. (J:188414)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Nostrin^tm1Oess/Nostrin^tm1Oess Tg(Tek-cre)12Flv/0	involves: 129S2/SvPas * C3H * C57BL/6

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms
cardiovascular system	√
abnormal vascular endothelial cell migration	√
decreased vascular endothelial cell proliferation	√
cellular	√
abnormal vascular endothelial cell migration	√
decreased vascular endothelial cell proliferation	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nostrin Mutation: 37 strains or lines available

References

• Original: J:188414 Kovacevic I, et al., The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development. EMBO J. 2012 Aug 1;31(15):3309-22
• All: 2 reference(s)