Dcc^{Tg(H2-Kb-Jak2*V617F)1Shmd}
Transgenic Allele Detail

Summary

• Symbol: Dcc^{Tg(H2-Kb-Jak2*V617F)1Shmd}
• Name: DCC netrin 1 receptor; transgene insertion 1, Kazuya Shimoda
• MGI ID: MGI:5444031
• Synonyms: JAK2 V617F
• Gene: Dcc Location: Chr18:71386705-72484140 bp, - strand Genetic Position: Chr18, 45.24 cM
• Alliance: Dcc^{Tg(H2-Kb-Jak2*V617F)1Shmd} page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Dcc^{Tg(H2-Kb-Jak2*V617F)1Shmd} expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Jak2 (MGI:96629)

• Mutation details: This transgene consists of murine Jak2 with a phenylalanine for valine substitution at residue 617 under the control of the H-2K^b promoter. The transgene integrated in intron 12 of Dcc in this line. (J:130189)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcc Mutation: 76 strains or lines available

References

• Original: J:130189 Shide K, et al., Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. Leukemia. 2008 Jan;22(1):87-95
• All: 2 reference(s)