Myc^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Myc^tm1.1Itl
• Name: myelocytomatosis oncogene; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5444112
• Synonyms: Myc 3' WRE^-
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188927
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced the 3' Wnt responsive DNA element (WRE). Flp-mediated recombination removed the neo cassette. RT-PCR confirmed increased transcript expression in the colon. (J:188927)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:188927 Konsavage WM Jr, et al., The Myc 3' Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol. 2012 Oct;32(19):3891-902
• All: 2 reference(s)