Gucy1b2^tm2Mom
Targeted Allele Detail

Summary

• Symbol: Gucy1b2^tm2Mom
• Name: guanylate cyclase 1, soluble, beta 2; targeted mutation 2, Peter Mombaerts
• MGI ID: MGI:5444154
• Synonyms: Gucy1b2-D-IRES-tauGFP, Gucy1b2-KO
• Gene: Gucy1b2 Location: Chr14:62630125-62693738 bp, - strand Genetic Position: Chr14, 33.21 cM
• Alliance: Gucy1b2^tm2Mom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235858
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Approximately 4.3 kb of DNA encoding the catalytic domain, spanning from partway through exon 12 to partway through of exon 15, was deleted, a stop codon and AscI site was generated in the middle of exon 12, and an IRES-tauGFP-pA ACNF cassette was inserted into the AscI site thus creating a null allele with GFP reporter. (J:235858)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gucy1b2 Mutation: 33 strains or lines available

References

• Original: J:235858 Bleymehl K, et al., A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium. Neuron. 2016 Dec 21;92(6):1196-1203
• All: 2 reference(s)