Gdf2^tm1Sjl
Targeted Allele Detail

Summary

• Symbol: Gdf2^tm1Sjl
• Name: growth differentiation factor 2; targeted mutation 1, Se-Jin Lee
• MGI ID: MGI:5444242
• Gene: Gdf2 Location: Chr14:33662996-33669155 bp, + strand Genetic Position: Chr14, 20.8 cM
• Alliance: Gdf2^tm1Sjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189049
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the entire coding sequence in exon 2. ELISA confirmed the absence of protein expression in the serum. (J:189049)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf2 Mutation: 25 strains or lines available

References

• Original: J:189049 Ricard N, et al., BMP9 and BMP10 are critical for postnatal retinal vascular remodeling. Blood. 2012 Jun 21;119(25):6162-71
• All: 9 reference(s)